This one, by Take 180, not only spoofs the movie, but Twi-Hards. You could choose to get offended. Obviously, we aren't as delusional as Devin, but we are kind of nuts (some of us more than others). You have to be able to laugh at yourself; otherwise you'll think the Volturi are sending you messages through your neighbor's dog to stalk RPattz.
I'm not a video game guy. I've never played "Call of Duty: Modern Warfare" let alone its sequels, and I still got every joke in this video by XPlay. All you need to know is Edward and Jacob join a task force in a real-life first-person shooter game. Sound too high concept? It's not. And it even gives old jokes (Jacob likes to be topless!) new life.
"SNL's" Digital Shorts are great at taking a simple concept and hammering it until they've wrung all the possible humor out of it. The premise here is replacing vampires with Frankenstein. They're both timeless characters, who viewers know. The punch lines almost write themselves, and by the end you may just find Frankie irresistible, too.